NYMC Faculty Publications

Cangrelor for Patients Undergoing Percutaneous Coronary Intervention: Evidence From a Meta-Analysis of Randomized Trials

Author Type(s)

Faculty

DOI

10.1007/s11239-013-0998-5

Journal Title

Journal of Thrombosis and Thrombolysis

First Page

1

Last Page

10

Document Type

Article

Publication Date

7-1-2014

Department

Medicine

Keywords

Adenosine Monophosphate, Female, Hemorrhage, Humans, Male, Models, Biological, Myocardial Infarction, Percutaneous Coronary Intervention, Postoperative Complications, PubMed, Purinergic P2Y Receptor Antagonists, Randomized Controlled Trials as Topic, Receptors, Purinergic P2Y12, Thrombosis

Disciplines

Medicine and Health Sciences

Abstract

Cangrelor is a new parenteral adenosine diphosphate P2Y12 receptor inhibitor with rapid, profound and reversible inhibition of platelet activity. The aim of this meta-analysis was to evaluate efficacy and safety of this new agent in patients undergoing percutaneous coronary intervention (PCI). We searched PubMed, Cochrane Library, EMBASE, Web of Science and CINAHL databases from the inception through April 2013. Randomized controlled trials (RCTs) comparing cangrelor with control (clopidogrel/placebo) were selected. We used the random-effects models to calculate the risk ratio. The primary efficacy outcome was risk of myocardial infarction, and the primary safety outcome was TIMI major bleeding at 48 h. Three RCTs included a total of 25,107 participants. Effects of Cangrelor were not different against comparators for myocardial infarction (MI) (Risk ratio [RR] 0.94, 95% confidence interval [CI] 0.78-1.13) and all-cause mortality (RR 0.72, 95% CI 0.36-1.43). However, cangrelor significantly reduced the risk of ischemia-driven revascularization (RR 0.72, 95% CI 0.52-0.98), stent thrombosis (RR 0.60, 95% CI 0.44-0.82) and Q wave MI (RR 0.53, 95% CI 0.30-0.92) without causing extra major bleeding (Thrombolysis in Myocardial infarction criteria) and severe or life-threatening bleeding (Global utilization of streptokinase and tissue plasminogen activator for occluded coronary arteries criteria). Separate analysis against only clopidogrel also showed similar findings except Q wave MI outcome. Use of cangrelor during PCI might reduce the risk of ischemia-driven revascularization and stent thrombosis, without causing extra major bleeding.

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