NYMC Faculty Publications

Plasmid-Related Quinolone Resistance Determinants in Epidemic Vibrio Parahaemolyticus, Uropathogenic Escherichia Coli, and Marine Bacteria From an Aquaculture Area in Chile

Author Type(s)

Faculty

DOI

10.1007/s00248-014-0409-2

Journal Title

Microbial Ecology

First Page

324

Last Page

328

Document Type

Article

Publication Date

8-1-2014

Department

Pathology, Microbiology and Immunology

Keywords

Amino Acid Sequence, Anti-Bacterial Agents, Aquaculture, Chile, Cloning, Molecular, DNA, Bacterial, Drug Resistance, Bacterial, Genes, Bacterial, Molecular Sequence Data, Mutation, Plasmids, Quinolones, Uropathogenic Escherichia coli, Vibrio parahaemolyticus

Disciplines

Medicine and Health Sciences

Abstract

Marine bacteria from aquaculture areas with industrial use of quinolones have the potential to pass quinolone resistance genes to animal and human pathogens. The VPA0095 gene, related to the quinolone resistance determinant qnrA, from clinical isolates of epidemic Vibrio parahaemolyticus conferred reduced susceptibility to quinolone after cloning into Escherichia coli K-12 either when acting alone or synergistically with DNA gyrase mutations. In addition, a plasmid-mediated quinolone resistance gene from marine bacteria, aac(6')-Ib-cr, was identical to aac(6')-Ib-cr from urinary tract isolates of E. coli, suggesting a recent flow of this gene between these bacteria isolated from different environments. aac(6')-Ib-cr from E. coli also conferred reduced susceptibility to quinolone and kanamycin when cloned into E. coli K-12.

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