NYMC Faculty Publications
Defining Risk Groups to Yellow Fever Vaccine-Associated Viscerotropic Disease in the Absence of Denominator Data
Author Type(s)
Faculty
DOI
10.4269/ajtmh.13-0542
Journal Title
The American Journal of Tropical Medicine and Hygiene
First Page
267
Last Page
271
Document Type
Article
Publication Date
2-1-2014
Department
Pathology, Microbiology and Immunology
Keywords
Adolescent, Adult, Aged, Child, Child, Preschool, Cluster Analysis, Confidence Intervals, Female, Humans, Infant, Male, Middle Aged, Odds Ratio, Risk Factors, Vaccination, Vaccines, Attenuated, Yellow Fever, Yellow Fever Vaccine, Yellow fever virus, Young Adult
Disciplines
Medicine and Health Sciences
Abstract
Several risk groups are known for the rare but serious, frequently fatal, viscerotropic reactions following live yellow fever virus vaccine (YEL-AVD). Establishing additional risk groups is hampered by ignorance of the numbers of vaccinees in factor-specific risk groups thus preventing their use as denominators in odds ratios (ORs). Here, we use an equation to calculate ORs using the prevalence of the factor-specific risk group in the population who remain well. The 95% confidence limits and P values can also be calculated. Moreover, if the estimate of the prevalence is imprecise, discrimination analysis can indicate the prevalence at which the confidence interval results in an OR of ∼1 revealing if the prevalence might be higher without yielding a non-significant result. These methods confirm some potential risk groups for YEL-AVD and cast doubt on another. They should prove useful in situations in which factor-specific risk group denominator data are not available.
Recommended Citation
Seligman, S. J., Cohen, J. E., Itan, Y., Casanova, J., & Pezzullo, J. C. (2014). Defining Risk Groups to Yellow Fever Vaccine-Associated Viscerotropic Disease in the Absence of Denominator Data. The American Journal of Tropical Medicine and Hygiene, 90 (2), 267-271. https://doi.org/10.4269/ajtmh.13-0542
