NYMC Faculty Publications
Hand, Foot and Scrotal Blisters in a Patient With Cancer Receiving Oral Chemotherapy
Author Type(s)
Faculty
DOI
10.1136/bcr-2013-202822
Journal Title
BMJ Case Reports
Document Type
Article
Publication Date
5-19-2014
Department
Medicine
Keywords
Administration, Oral, Administration, Topical, Adrenal Cortex Hormones, Aged, Blister, Carcinoma, Hepatocellular, Drug Eruptions, Foot Dermatoses, Hand Dermatoses, Humans, Liver Neoplasms, Lung Neoplasms, Male, Niacinamide, Phenylurea Compounds, Prognosis, Protein Kinase Inhibitors, Scrotum, Severity of Illness Index, Sorafenib, Syndrome, Treatment Outcome
Disciplines
Medicine and Health Sciences
Abstract
Tyrosine kinase inhibitors are novel antineoplastic drugs that make use of the molecular abnormalities that have been discovered in certain types of tumours. These agents are associated with important dermatological side effects. This case report discusses an atypical presentation of the hand-foot syndrome in one patient treated with sorafenib. A 78-year-old man, recently started on sorafenib for the treatment of hepatocarcinoma with lung metastasis, presented to the emergency room with painful blistering lesions on the palms, soles and scrotum for 1 week. A punch biopsy was performed and sorafenib was withheld. Direct immunofluorescence study was negative for an autoimmune blistering disorder and histopathology stains did not show any microorganisms. A diagnosis of hand-foot syndrome was made. After 2 weeks, the patient showed marked improvement and the plan was to restart sorafenib at a lower dosage.
Recommended Citation
Guerra, J., Suelves, A. M., Bella, A., & Lolo, D. (2014). Hand, Foot and Scrotal Blisters in a Patient With Cancer Receiving Oral Chemotherapy. BMJ Case Reports, 2014. https://doi.org/10.1136/bcr-2013-202822
