NYMC Faculty Publications

Update on Pharmacologic Therapy for Pulmonary Embolism

Author Type(s)

Faculty

DOI

10.1177/1074248413506612

Journal Title

Journal of Cardiovascular Pharmacology and Therapeutics

First Page

159

Last Page

169

Document Type

Article

Publication Date

3-1-2014

Department

Pharmacology

Keywords

Animals, Anticoagulants, Aspirin, Fibrinolytic Agents, Heparin, Low-Molecular-Weight, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Pulmonary Embolism, Warfarin

Disciplines

Medicine and Health Sciences

Abstract

Warfarin, unfractionated heparin (UFH), and low-molecular-weight heparins are anticoagulants that have been used for treatment of pulmonary embolism. Currently approved drugs for treatment of venous thromboembolism include UFH, enoxaparin, dalteparin, fondaparinux, warfarin, and rivaroxaban. The advent of newer oral anticoagulants such as rivaroxaban, dabigatran, and apixaban has provided us with alternative therapeutic options for long-term anticoagulation. This article will give an overview of the various anticoagulant drugs, use in various clinical scenarios, data supporting their clinical use, and recommendations regarding duration of anticoagulant therapy.

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