NYMC Faculty Publications

An Integrated Approach to Individualized Optimal Dose Estimation of Medication by Means of Dosing Adjustment Measures and Bi-Digital O-Ring Test

Author Type(s)

Faculty

DOI

10.3727/036012914X13966138791109

Journal Title

Acupuncture & Electro-Therapeutics Research

First Page

1

Last Page

25

Document Type

Article

Publication Date

1-1-2014

Department

Medicine

Keywords

Dosage Forms, Drug Compounding, Drug Dosage Calculations, History, 20th Century, History, 21st Century, Humans

Disciplines

Medicine and Health Sciences

Abstract

Posology concerns science and system of dosage. Conventionally the dosage systems of measurement are the apothecaries' and metric systems and the dosage calculation for each individual patient has been suggested according to several available methods, namely Clark's Rule, Fried's Rule, Young's Rule, body surface area, or mg/kg, etc. There are many factors affect the availability of a drug to its site of action in the body, and their relation to the time course of drug action and variation in each drug response with or without the other drugs taken simultaneously. The correct dosage requires meticulous and accurate calculation. In busy offices, some may feel the dosage calculation is tedious. This article reviews the conventional methods of dosage calculations and the allergy tests, followed by describing a simple way to determine the proper dosage for each patient by simplifying the Clark's concept based on the body weight and verify the optimum dosage with Bi-Digital O-Ring Test minimize the adverse drug reactions and to increase safety for drug administration.

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