NYMC Faculty Publications

Pathogenesis and Prevention of Intraventricular Hemorrhage

Author Type(s)

Faculty

DOI

10.1016/j.clp.2013.09.007

Journal Title

Clinics in Perinatology

First Page

47

Last Page

67

Document Type

Article

Publication Date

3-1-2014

Department

Pediatrics

Keywords

Astrocytes, Basement Membrane, Cerebral Hemorrhage, Cerebral Ventricles, Cerebrovascular Circulation, Fibronectins, Glial Fibrillary Acidic Protein, Glucocorticoids, Humans, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Neovascularization, Physiologic, Pericytes

Disciplines

Medicine and Health Sciences

Abstract

Intraventricular hemorrhage (IVH) is a major neurologic complication of prematurity. Pathogenesis of IVH is attributed to intrinsic fragility of germinal matrix vasculature and to the fluctuation in the cerebral blood flow. Germinal matrix exhibits rapid angiogenesis orchestrating formation of immature vessels. Prenatal glucocorticoid exposure remains the most effective means of preventing IVH. Therapies targeted to enhance the stability of the germinal matrix vasculature and minimize fluctuation in the cerebral blood flow might lead to more effective strategies in preventing IVH.

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