NYMC Faculty Publications
Bioimpedance Monitoring of Cellular Hydration During Hemodialysis Therapy
DOI
10.1111/hdi.12511
Journal Title
Hemodialysis International.International Symposium on Home Hemodialysis
First Page
575
Last Page
584
Document Type
Article
Publication Date
October 2017
Department
Medicine
Abstract
Introduction The aim of this paper is to describe and demonstrate how a new bioimpedance analytical procedure can be used to monitor cellular hydration of End Stage Renal Disease (ESRD) patients during hemodialysis (HD). Methods A tetra-polar bioimpedance spectroscope (BIS), (UFI Inc., Morro Bay, CA), was used to measure the tissue resistance and reactance of the calf of 17 ESRD patients at 40 discrete frequencies once a minute during dialysis treatment. These measurements were then used to derive intracellular, interstitial, and intravascular compartment volume changes during dialysis. Findings The mean (+/- SD) extracellular resistance increased during dialysis from 92.4 +/- 3.5 to 117.7 +/- 5.8 Ohms. While the mean intracellular resistance decreased from 413.5 +/- 11.7 to 348.5 +/- 8.2 Ohms. It was calculated from these data that the mean intravascular volume fell 9.5%; interstitial volume fell 33.4%; and intracellular volume gained 20.3%. Discussion These results suggest that an extensive fluid shift into the cells may take place during HD. The present research may contribute to a better understanding of how factors that influence fluid redistribution may affect an ESRD patient during dialysis. In light of this finding, it is concluded that the rate of vascular refill is jointly determined with the rate of "cellular refill" and the transfer of fluid from the intertitial compartment into the intravascular space.
Recommended Citation
Montgomery, L., Montgomery, R., Gerth, W., Lew, S., Klein, M., Stewart, J., Medow, M., & Velasquez, M. (2017). Bioimpedance Monitoring of Cellular Hydration During Hemodialysis Therapy. Hemodialysis International.International Symposium on Home Hemodialysis, 21 (4), 575-584. https://doi.org/10.1111/hdi.12511