Sophoraflavenone G Restricts Dengue and Zika Virus Infection Via RNA Polymerase Interference

Authors

A Sze
D Olagnier
S Hadj
X Han
X Tian
H Xu
Long Yang, New York Medical College
Q Shi
Penghua Wang, New York Medical CollegeFollow
M Wainberg
J Wu
R LinFollow

DOI

10.3390/v9100287

Journal Title

Viruses

First Page

287

Document Type

Article

Publication Date

10-1-2017

Department

Pathology, Microbiology and Immunology

Abstract

Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research.

Recommended Citation

Sze, A., Olagnier, D., Hadj, S., Han, X., Tian, X., Xu, H., Yang, L., Shi, Q., Wang, P., Wainberg, M., Wu, J., & Lin, R. (2017). Sophoraflavenone G Restricts Dengue and Zika Virus Infection Via RNA Polymerase Interference. Viruses, 9 (10), 287. https://doi.org/10.3390/v9100287

Publisher's Statement

Originally published in Viruses 2017, 9, 28. The original material can be found here.

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.