NYMC Faculty Publications

Cardiovascular Manifestations of Hemochromatosis: A Review of Pathophysiology, Mechanisms, and Treatment Options

Author Type(s)

Faculty

DOI

10.1097/CRD.0000000000000622

Journal Title

Cardiology in Review

First Page

359

Last Page

364

Document Type

Article

Publication Date

7-1-2025

Department

Medicine

Keywords

cardiomyopathy, hemochromatosis, hepatocellular carcinoma, HFE gene, iron, reactive oxygen species

Disciplines

Medicine and Health Sciences

Abstract

Hemochromatosis is a genetic disorder characterized by excessive absorption and accumulation of iron in the body. It is one of the most common inherited disorders. The excess iron deposition can cause damage to various organs, including the liver, heart, pancreas, and joints. If left untreated, hemochromatosis can lead to serious complications such as cirrhosis, diabetes, heart failure, and increased risk of certain cancers. Iron overload in hemochromatosis significantly affects the cardiovascular system, leading to morbidity and mortality. This article reviews the current literature describing the pathogenesis and various cardiovascular manifestations of hemochromatosis, including dilated cardiomyopathy, conduction abnormalities, heart failure, cardiac fibrosis, myocardial infarction, and valvular heart disease. This article aims to provide a detailed understanding of the cardiovascular manifestations associated with hemochromatosis and their underlying mechanisms through a review of current literature in publicly available databases.

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