NYMC Faculty Publications
Inflammatory Modulation by Cord Blood Stem Cells Prevented Digit Deformation in Recessive Dystrophic Epidermolysis Bullosa
Author Type(s)
Student, Faculty
DOI
10.1016/j.ymthe.2025.08.038
Journal Title
Molecular Therapy
First Page
5427
Last Page
5441
Document Type
Article
Publication Date
11-5-2025
Department
Pediatrics
Keywords
IL-1, immunomodulation, inflammation, LIF, RDEB, unrestricted somatic stem cells
Disciplines
Medicine and Health Sciences
Abstract
Unrestricted somatic stem cells (USSCs) ameliorated fibrosis, enhanced motility, and improved survival in an RDEB mouse model by modulating IL-1-driven inflammation and promoting wound-healing macrophages. LIF secretion from USSCs suppressed IL-1α and increased IL-1Ra in macrophages, highlighting the therapeutic potential of stem cell-mediated paracrine signaling in RDEB.
Recommended Citation
Anderson-Crannage, M., Nyström, A., Hirani, R., Schaefer, E., Hochberg, B., Kann, R., Pan, J., Tian, M., Zhu, H., Luo, W., Ayello, J., Cairo, M., & Liao, Y. (2025). Inflammatory Modulation by Cord Blood Stem Cells Prevented Digit Deformation in Recessive Dystrophic Epidermolysis Bullosa. Molecular Therapy, 33 (11), 5427-5441. https://doi.org/10.1016/j.ymthe.2025.08.038
