NYMC Faculty Publications

Prognostic Effect of Frailty in Cerebral Venous Thrombosis

Author Type(s)

Faculty

DOI

10.1016/j.jns.2025.123695

Journal Title

Journal of the Neurological Sciences

Document Type

Article

Publication Date

11-15-2025

Department

Neurology

Keywords

Cerebral venous thrombosis, Database, Frailty, Outcome, Stroke

Disciplines

Medicine and Health Sciences

Abstract

Introduction: Few studies have evaluated the role of frailty in cerebral venous thrombosis (CVT), perhaps due to the relative rarity of the pathology and its predominance in younger populations. We aim to do so using a large, nationally representative sample. Methods: Hospitalization records for CVT were identified in the National Inpatient Sample (2016–2020) and the cohort was stratified by increasing frailty thresholds, quantified by the Risk Analysis Index (RAI). Effect sizes of frailty tiers for poor outcome (defined as non-routine discharge disposition) produced from multivariable logistic regression models and discrimination (c-statistic) were evaluated. Results: This analysis identified 3265 CVT hospitalizations (median age 56 years, 59.6 % female). Following cohort stratification, 465 (14.2 %) were frail and 160 (4.9 %) were very frail. A poor outcome was experienced by 58.7 %, and the rate of poor outcome as well as mean baseline NIHSS score increased as a function of increasing frailty tier. Following multivariable logistic regression analysis, all frailty tiers of the categorical RAI were significantly associated with poor outcome. A combined RAI-NIHSS model achieved a c-statistic of 0.828 (95 % CI 0.796, 0.860). Conclusion: Concomitant consideration of frailty quantified by the RAI and baseline NHSS score reliably predicts short-term outcome in CVT.

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