NYMC Faculty Publications
Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association
Author Type(s)
Faculty
DOI
10.1161/CIR.0000000000000296
Journal Title
Circulation
First Page
1435
Last Page
1486
Document Type
Article
Publication Date
10-13-2015
Department
Pediatrics
Keywords
Adult, Anti-Infective Agents, Anticoagulants, Bacteremia, Candidiasis, Diagnostic Techniques, Cardiovascular, Endocarditis, Heart Valve Prosthesis, Humans, Prosthesis-Related Infections, Rheumatic Heart Disease, Risk Factors, Staphylococcal Infections, Streptococcal Infections
Disciplines
Medicine and Health Sciences
Abstract
BACKGROUND: Infective endocarditis is a potentially lethal disease that has undergone major changes in both host and pathogen. The epidemiology of infective endocarditis has become more complex with today's myriad healthcare-associated factors that predispose to infection. Moreover, changes in pathogen prevalence, in particular a more common staphylococcal origin, have affected outcomes, which have not improved despite medical and surgical advances.
METHODS AND RESULTS: This statement updates the 2005 iteration, both of which were developed by the American Heart Association under the auspices of the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease of the Young. It includes an evidence-based system for diagnostic and treatment recommendations used by the American College of Cardiology and the American Heart Association for treatment recommendations.
CONCLUSIONS: Infective endocarditis is a complex disease, and patients with this disease generally require management by a team of physicians and allied health providers with a variety of areas of expertise. The recommendations provided in this document are intended to assist in the management of this uncommon but potentially deadly infection. The clinical variability and complexity in infective endocarditis, however, dictate that these recommendations be used to support and not supplant decisions in individual patient management.
Recommended Citation
Baddour, L. M., Wilson, W. R., Bayer, A. S., Fowler, V. G., Tleyjeh, I. M., Rybak, M. J., Barsic, B., Lockhart, P. B., Gewitz, M. H., Levison, M. E., Bolger, A. F., Steckelberg, J. M., Baltimore, R. S., Fink, A. M., O'Gara, P., & Taubert, K. A. (2015). Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation, 132 (15), 1435-1486. https://doi.org/10.1161/CIR.0000000000000296
