NYMC Faculty Publications
Pathogenesis of Endothelial Cell Dysfunction in Chronic Kidney Disease: A Retrospective and What the Future May Hold
Author Type(s)
Faculty
DOI
10.1016/j.krcp.2015.05.003
Journal Title
Kidney Research and Clinical Practice
First Page
76
Last Page
82
Document Type
Article
Publication Date
6-1-2015
Department
Medicine
Disciplines
Medicine and Health Sciences
Abstract
Cardiovascular complications dominate the landscape of chronic kidney diseases (CKD). Endothelial cell dysfunction (ECD) is a well-known culprit of cardiovascular morbidity and it develops in CKD with remarkable frequency. This brief overview of ECD in CKD scans two decades of studies performed in my laboratory, from genetic analyses to proteomic and metabolomics screens. I provide a detailed description of findings related to the premature senescence of endothelial cells, cell transition from the endothelial to mesenchymal phenotype, and stages of development of ECD. Clinical utility of some of these findings is illustrated with data on laser-Doppler flowmetry and imaging in patients with CKD. Some currently available and emerging therapeutic options for the management of ECD are briefly presented.
Recommended Citation
Goligorsky, M. S. (2015). Pathogenesis of Endothelial Cell Dysfunction in Chronic Kidney Disease: A Retrospective and What the Future May Hold. Kidney Research and Clinical Practice, 34 (2), 76-82. https://doi.org/10.1016/j.krcp.2015.05.003
