NYMC Faculty Publications

Outcomes of Mechanical Thrombectomy in Anticoagulated Patients With Acute Distal and Medium Vessel Stroke

Author Type(s)

Faculty

DOI

10.1177/23969873241249295

Journal Title

European Stroke Journal

First Page

896

Last Page

906

Document Type

Article

Publication Date

12-2024

Keywords

Humans, Aged, Male, Female, Anticoagulants, Retrospective Studies, Ischemic Stroke, Aged, 80 and over, Thrombectomy, Treatment Outcome, Middle Aged, Stroke

Disciplines

Medicine and Health Sciences

Abstract

BACKGROUND: Stroke remains a major health concern globally, with oral anticoagulants widely prescribed for stroke prevention. The efficacy and safety of mechanical thrombectomy (MT) in anticoagulated patients with distal medium vessel occlusions (DMVO) are not well understood.

METHODS: This retrospective analysis involved 1282 acute ischemic stroke (AIS) patients who underwent MT in 37 centers across North America, Asia, and Europe from September 2017 to July 2023. Data on demographics, clinical presentation, treatment specifics, and outcomes were collected. The primary outcomes were functional outcomes at 90 days post-MT, measured by modified Rankin Scale (mRS) scores. Secondary outcomes included reperfusion rates, mortality, and hemorrhagic complications.

RESULTS: Of the patients, 223 (34%) were on anticoagulation therapy. Anticoagulated patients were older (median age 78 vs 74 years;

CONCLUSION: Anticoagulated patients undergoing MT for AIS due to DMVO did not show significant differences in 90-day mRS outcomes, reperfusion, or hemorrhage compared to non-anticoagulated patients after adjustment for covariates.

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