NYMC Faculty Publications
Estimated Glucose Disposal Rate and the Risk of Major Adverse Cardio-Cerebrovascular Outcomes and Mortality in Patients Undergoing Percutaneous Coronary Intervention: a Retrospective Cohort Study
Author Type(s)
Faculty
DOI
10.1186/s40001-025-02690-5
Journal Title
European Journal of Medical Research
First Page
442
Last Page
442
Document Type
Article
Publication Date
6-2-2025
Department
Medicine
Keywords
Humans, Percutaneous Coronary Intervention, Male, Female, Retrospective Studies, Middle Aged, Aged, Blood Glucose, Cerebrovascular Disorders, Risk Factors, Insulin Resistance, Diabetes Mellitus, Cardiovascular Diseases
Disciplines
Medicine and Health Sciences
Abstract
BACKGROUND: While percutaneous coronary intervention (PCI) has improved survival rates, many patients remain at risk for future adverse cardio-cerebral events. This study explores the role of insulin resistance, measured by the estimated glucose disposal rate (eGDR), as a potential predictor of cardio-cerebrovascular outcomes and mortality.
METHODS: This retrospective analysis included patients who underwent PCI at our center between 2015 and 2020. Patients were categorized by glycemic status into individuals with diabetes (DM), pre-DM and normal glucose levels. Our primary outcome was major adverse cardiac and cerebrovascular event (MACCE).
RESULTS: We included 2144 patients-236 patients with pre-DM, 1735 with DM, and 173 with normal glucose levels. After a mean follow-up of 550 days, patients with pre-DM in the Q3 and Q4 quartiles of eGDR were less likely to experience MACCE (HR: 0.172, 95% CI 0.036-0.813 and HR: 0.096, 95% CI 0.013-0.713, respectively). In the DM and non-DM groups, there was no significant relationship between eGDR and MACCE. After adjustment for lipid profile and history of statin medication, results remained consistent for both Q3 and Q4 in pre-DM subgroup with lower rate of MACCE (HR: 0.168, 95% CI 0.033-0.820) and (HR: 0.099, 95% CI 0.012-0.814). Additionally, the Q4 compared to Q1 in the non-DM group demonstrated significantly lower MACCE (HR: 0.000, 95% CI 0.000-0.759).
CONCLUSIONS: Our findings suggest that eGDR could be an important tool for assessing risk for future cardio-cerebral events and mortality in patients with pre-DM and normal glycemic levels who undergo PCI. However, its predictive power in patients with DM appears to be limited.
Recommended Citation
Shojaei, S., Mousavi, A., Arzhangzadeh, A., Salabat, D., Pourfaraji, S., Shirmard, F., Soleimani, H., Khanipour, R., Ashraf, H., Masoudkabir, F., Almandoz, J. P., Nelson, J. R., Anil, H., Aronow, W., & Hosseini, K. (2025). Estimated Glucose Disposal Rate and the Risk of Major Adverse Cardio-Cerebrovascular Outcomes and Mortality in Patients Undergoing Percutaneous Coronary Intervention: a Retrospective Cohort Study. European Journal of Medical Research, 30 (1), 442-442. https://doi.org/10.1186/s40001-025-02690-5
