NYMC Faculty Publications
Regulation of Coronary Blood Flow in Health and Ischemic Heart Disease
Author Type(s)
Faculty
DOI
10.1016/j.pcad.2014.12.002
Journal Title
Progress in Cardiovascular Diseases
First Page
409
Last Page
422
Document Type
Article
Publication Date
1-1-2015
Department
Physiology
Keywords
Animals, Coronary Circulation, Coronary Vessels, Hemodynamics, Homeostasis, Humans, Microcirculation, Models, Cardiovascular, Myocardial Ischemia, Regional Blood Flow, Ventricular Function, Left
Disciplines
Medicine and Health Sciences
Abstract
The major factors determining myocardial perfusion and oxygen delivery have been elucidated over the past several decades, and this knowledge has been incorporated into the management of patients with ischemic heart disease (IHD). The basic understanding of the fluid mechanical behavior of coronary stenoses has also been translated to the cardiac catheterization laboratory where measurements of coronary pressure distal to a stenosis and coronary flow are routinely obtained. However, the role of perturbations in coronary microvascular structure and function, due to myocardial hypertrophy or coronary microvascular dysfunction, in IHD is becoming increasingly recognized. Future studies should therefore be aimed at further improving our understanding of the integrated coronary microvascular mechanisms that control coronary blood flow, and of the underlying causes and mechanisms of coronary microvascular dysfunction. This knowledge will be essential to further improve the treatment of patients with IHD.
Recommended Citation
Duncker, D., Koller, A., Merkus, D., & Canty, J. (2015). Regulation of Coronary Blood Flow in Health and Ischemic Heart Disease. Progress in Cardiovascular Diseases, 57 (5), 409-422. https://doi.org/10.1016/j.pcad.2014.12.002
