NYMC Faculty Publications

Takotsubo Syndrome (or Apical Ballooning Syndrome) Secondary to Zolmitriptan

Author Type(s)

Faculty

DOI

10.1097/01.mjt.0000433938.07244.05

Journal Title

American Journal of Therapeutics

First Page

52

Last Page

56

Document Type

Article

Publication Date

1-1-2015

Department

Medicine

Keywords

Chest Pain, Coronary Angiography, Electrocardiography, Female, Humans, Middle Aged, Migraine Disorders, Oxazolidinones, Serotonin 5-HT1 Receptor Agonists, Takotsubo Cardiomyopathy, Tryptamines

Disciplines

Medicine and Health Sciences

Abstract

Takotsubo syndrome (TS), also known as broken heart syndrome, is characterized by left ventricle apical ballooning with elevated cardiac biomarkers and electrocardiographic changes suggestive of an acute coronary syndrome (ie, ST-segment elevation, T wave inversions, and pathologic Q waves). We report a case of 54-year-old woman with medical history of mitral valve prolapse and migraines, who was admitted to the hospital for substernal chest pain and electrocardiogram demonstrated 1/2 mm ST-segment elevation in leads II, III, aVF, V5, and V6 and positive troponin I. Emergent coronary angiogram revealed normal coronary arteries with moderately reduced left ventricular ejection fraction with wall motion abnormalities consistent with TS. Detailed history obtained retrospectively revealed that the patient took zolmitriptan sparingly only when she had migraines. But before this event, she was taking zolmitriptan 2-3 times daily for several days because of a persistent migraine headache. She otherwise reported that she is quite active, rides horses, and does show jumping without any limitations in her physical activity. There was no evidence of any recent stress or status migrainosus. Extensive literature search revealed multiple cases of coronary artery vasospasm secondary to zolmitriptan, but none of the cases were associated with TS.

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