NYMC Faculty Publications

Understanding the Association Between Long COVID, Neurological Symptoms, and Anxiety

DOI

10.3390/covid5100177

Journal Title

Covid

Document Type

Article

Publication Date

10-1-2025

Department

Medicine

Keywords

anxiety, attention, brain fog, long COVID, neurological symptoms, psychological distress

Disciplines

Medicine and Health Sciences

Abstract

Long COVID, characterized by persistent symptoms following COVID-19 infection, poses significant challenges to individuals’ well-being. This study explores the multifaceted nature of long COVID, encompassing neurological and psychological manifestations. Neurological symptoms, including difficulty thinking clearly (brain fog) and concentrating, are prominent features of long COVID, drawing increasing attention due to their potential long-term adverse impact on the patient’s daily functioning and quality of life. Furthermore, anxiety emerges as a prevalent psychological concern among individuals with long COVID, exacerbating the uncertainty and distress associated with the ongoing symptoms of the virus. Despite growing recognition of the interplay between long COVID, neurological symptoms, and anxiety, there remains a notable gap in the literature regarding the specific relationship between these domains. This study addresses this gap by investigating how the presence of long COVID symptoms relates to the manifestation of neurological symptoms, with anxiety as a potential mediator. Utilizing data from the COVID-19 Health and Mental Health Survey, this research provides insights into the complex interplay between long COVID, neurological symptoms, and anxiety. This research provides a deeper understanding of the long-term implications of this virus and informs assessment and intervention for these patients.

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