NYMC Faculty Publications

Neurotransmission Sex Dichotomy in the Rat Hypothalamic Paraventricular Nucleus in Healthy and Infantile Spasm Model

DOI

10.3390/cimb47050380

Journal Title

Current Issues in Molecular Biology

Document Type

Article

Publication Date

5-1-2025

Department

Cell Biology and Anatomy

Keywords

Adcy5, cholinergic synapse, dopaminergic synapse, GABAergic synapse, glutamatergic synapse, serotonergic synapse, synaptic vesicle cycle, transcriptomic network

Disciplines

Medicine and Health Sciences

Abstract

We profiled the gene expressions in the hypothalamic paraventricular nuclei of 12 male and 12 female pups from a standard rat model of infantile spasms to determine the sex dichotomy of the neurotransmission genomic fabrics. Infantile spasms were triggered in rat pups prenatally primed with two doses of betamethasone followed by the postnatal repeated administration of N-methyl-D-aspartic acid to induce spasms. Publicly available microarray data were used to characterize each gene in each condition for both sexes by the independent transcriptomic features: average expression level, control of the transcript abundance, and expression correlation with every other gene. This study revealed substantial sex differences in the expression level, control, and inter-coordination of the investigated genes among the studied groups. The transcriptomic differences assist in providing a molecular explanation of the behavioral differences and development of infantile epilepsy spasm syndrome in the two sexes.

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