WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects

Authors

K Yokote
S Chanprasert
L Lee
K Eirich
M Takemoto
A Watanabe
Karen Seiter, New York Medical CollegeFollow
G MartinFollow
A Chateau
K Deguchi
T Easwar
A Federico
A Fox
T Grebe
B Hay
S Nampoothiri
Karen Seiter, New York Medical CollegeFollow
E Streeten
R Pina-Aguilar
G Poke
M Poot
R Posmyk
G MartinFollow
C Kubisch
D Schindler
J Oshima

DOI

10.1002/humu.23128

Journal Title

Human Mutation

First Page

7

Last Page

15

Document Type

Article

Publication Date

January 2017

Department

Medicine

Abstract

Werner syndrome (WS) is a rare autosomal recessive disorder characterized by a constellation of adult onset phenotypes consistent with an acceleration of intrinsic biological aging. It is caused by pathogenic variants in the WRN gene, which encodes a multifunctional nuclear protein with exonuclease and helicase activities. WRN protein is thought to be involved in optimization of various aspects of DNA metabolism, including DNA repair, recombination, replication, and transcription. In this update, we summarize a total of 83 different WRN mutations, including eight previously unpublished mutations identified by the International Registry of Werner Syndrome (Seattle, WA) and the Japanese Werner Consortium (Chiba, Japan), as well as 75 mutations already reported in the literature. The Seattle International Registry recruits patients from all over the world to investigate genetic causes of a wide variety of progeroid syndromes in order to contribute to the knowledge of basic mechanisms of human aging. Given the unusually high prevalence of WS patients and heterozygous carriers in Japan, the major goal of the Japanese Consortium is to develop effective therapies and to establish management guidelines for WS patients in Japan and elsewhere. This review will also discuss potential translational approaches to this disorder, including those currently under investigation.

Comments

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Recommended Citation

Yokote, K., Chanprasert, S., Lee, L., Eirich, K., Takemoto, M., Watanabe, A., Seiter, K., Martin, G., Chateau, A., Deguchi, K., Easwar, T., Federico, A., Fox, A., Grebe, T., Hay, B., Nampoothiri, S., Seiter, K., Streeten, E., Pina-Aguilar, R., Poke, G., Poot, M., Posmyk, R., Martin, G., Kubisch, C., Schindler, D., & Oshima, J. (2017). WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects. Human Mutation, 38 (1), 7-15. https://doi.org/10.1002/humu.23128