NYMC Faculty Publications

Vascular Actions of 20-HETE

Author Type(s)

Faculty

Additional Author Affiliation

Touro College

DOI

10.1016/j.prostaglandins.2015.03.002

Journal Title

Prostaglandins & Other Lipid Mediators

First Page

9

Last Page

16

Document Type

Article

Publication Date

7-1-2015

Department

Pharmacology

Keywords

Animals, Blood Vessels, Humans, Hydroxyeicosatetraenoic Acids, Neovascularization, Physiologic, Renin-Angiotensin System, Vascular Diseases, Vascular Remodeling

Disciplines

Medicine and Health Sciences

Abstract

20-hydroxyeicosatetraenoic acid (20-HETE) is a metabolite of arachidonic acid that exhibits a myriad of biological effects in the vascular system. This review discusses the current knowledge related to the effects of 20-HETE on vascular reactivity, activation, and remodeling, as well as its role in vascular inflammation and angiogenesis. The information explaining how 20-HETE and the renin-angiotensin system interact to promote hypertension, vasoconstriction, and vascular dysfunction is summarized in this article. 20-HETE enhances vascular inflammation and injury in models of diabetes, ischemia/reperfusion, and cerebrovascular oxidative stress. Recent studies also established a role for 20-HETE in normal and pathological angiogenesis conditions. This review will also discuss the molecular mechanisms through which 20-HETE induces these vascular actions. Potential additional studies are suggested to address shortcomings in the current knowledge of 20-HETE in the vascular system.

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