NYMC Faculty Publications

Direct Myocardial Ischemia Imaging: A New Cardiovascular Nuclear Imaging Paradigm

Author Type(s)

Faculty

DOI

10.1002/clc.22346

Journal Title

Clinical Cardiology

First Page

124

Last Page

130

Document Type

Article

Publication Date

2-1-2015

Department

Medicine

Keywords

Coronary Circulation, Humans, Myocardial Ischemia, Myocardial Perfusion Imaging, Positron-Emission Tomography, Predictive Value of Tests, Prognosis, Radiopharmaceuticals, Tomography, Emission-Computed, Single-Photon

Disciplines

Medicine and Health Sciences

Abstract

Myocardial perfusion imaging (MPI), using radiotracers, has been in routine clinical use for over 40 years. This modality is used for the detection of coronary artery disease (CAD), risk stratification, optimizing therapy, and follow-up of patients with CAD. Molecular cardiovascular imaging using targeted radiotracers provides a unique opportunity for imaging biochemical and metabolic processes, and cell membrane transporter and receptor functions at a cellular and molecular level in experimental animal models as well as in humans. Cardiac imaging using radiolabeled free fatty acid analogues and glucose analogues enable us to image myocardial ischemia directly as an alternative to stress-rest MPI. Direct ischemia imaging techniques can avoid and overcome some of the limitations of standard stress-rest MPI. This article describes recent studies using (18) F-fluorodeoxyglucose ((18) FDG) for myocardial ischemia imaging.

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