NYMC Faculty Publications

Associations of Obsessive-Compulsive Symptoms With Clinical and Neurocognitive Features in Schizophrenia According to Stage of Illness

Author Type(s)

Faculty

DOI

10.1016/j.psychres.2015.01.021

Journal Title

Psychiatry Research

First Page

368

Last Page

375

Document Type

Article

Publication Date

3-30-2015

Department

Psychiatry and Behavioral Sciences

Keywords

Adult, Antipsychotic Agents, Comorbidity, Depression, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Personality Inventory, Psychiatric Status Rating Scales, Psychotic Disorders, Quality of Life, Risperidone, Schizophrenia, Schizophrenic Psychology, Severity of Illness Index

Disciplines

Medicine and Health Sciences

Abstract

This study aimed to investigate the association of obsessive-compulsive symptoms with clinical and neurocognitive features in patients with schizophrenia. This study enrolled 163 people with schizophrenia who were receiving risperidone monotherapy. Comorbid obsessive-compulsive symptoms were assessed using the Yale-Brown Obsessive-Compulsive Scale, and subjects with a score ≥ 10 constituted the obsessive-compulsive symptom group (n=30, 18.4%). The learning index was significantly higher in patients with obsessive-compulsive symptoms than in those without such symptoms after adjusting for age, stage (early and chronic), duration of illness, and CDSS score. However, there was no significant interaction between obsessive-compulsive symptoms and stage of illness. Scores on Positive and Negative Syndrome Scale, Calgary Depression Scale for Schizophrenia, and Beck Depression Inventory were significantly higher in the obsessive-compulsive symptom group. In addition, the Subjective Well-being under Neuroleptic Treatment score was significantly lower in the obsessive-compulsive symptom group. In conclusion, comorbid obsessive-compulsive symptoms in patients with schizophrenia were associated with a higher learning ability without a significant interaction with stage of illness. However, schizophrenia patients with obsessive-compulsive symptoms had more severe psychotic and depressive symptoms and poorer quality of life.

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