Modeling Schizophrenia Pathogenesis Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs)

Authors

H Noh
Z Shao
J Coyle
Sangmi Chung, New York Medical CollegeFollow

DOI

10.1016/j.bbadis.2017.06.019

Journal Title

Biochimica Et Biophysica Acta-Molecular Basis of Disease

First Page

2382

Last Page

2387

Document Type

Article

Publication Date

9-1-2017

Department

Cell Biology and Anatomy

Keywords

Induced Pluripotent Stem Cells, Schizophrenia pathology

Disciplines

Medicine and Health Sciences | Psychiatric and Mental Health | Psychiatry and Psychology

Abstract

Schizophrenia is a chronic disabling mental disorder that affects about 1% population world-wide, for which there is a desperate need to develop more effective treatments. In this minireview, we summarize the findings from recent studies using induced pluripotent stem cells to model the developmental pathogenesis of schizophrenia and discuss what we have learned from these studies. We also discuss what are the important next steps and key issues to be addressed to move the field forward.

Recommended Citation

Noh, H., Shao, Z., Coyle, J., & Chung, S. (2017). Modeling Schizophrenia Pathogenesis Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs). Biochimica Et Biophysica Acta-Molecular Basis of Disease, 1863 (9), 2382-2387. https://doi.org/10.1016/j.bbadis.2017.06.019