Redox Mechanisms Influencing cGMP Signaling in Pulmonary Vascular Physiology and Pathophysiology

Authors

D PatelFollow
Anand Lakhkar, New York Medical College
Michael Wolin, New York Medical CollegeFollow

DOI

10.1007/978-3-319-63245-2_13

First Page

227

Last Page

240

Document Type

Book Chapter

Publication Date

10-18-2017

Department

Physiology

Abstract

The soluble form of guanylate cyclase (sGC) and cGMP signaling are major regulators of pulmonary vasodilation and vascular remodeling that protect the pulmonary circulation from hypertension development. Nitric oxide, reactive oxygen species, thiol and heme redox, and heme biosynthesis control mechanisms regulating the production of cGMP by sGC. In addition, a cGMP-independent mechanism regulates protein kinase G through thiol oxidation in manner controlled by peroxide metabolism and NADPH redox. Multiple aspects of these regulatory processes contribute to physiological and pathophysiological regulation of the pulmonary circulation, and create potentially novel therapeutic targets for the treatment of pulmonary vascular disease.

Recommended Citation

Patel D, Lakhkar A, Wolin MS. Redox mechanisms influencing cGMP signaling in pulmonary vascular physiology and pathophysiology. In: Wang YX, editor. Pulmonary vasculature redox signaling in health and disease. Adv Exp Med Biol. Vol. 967. Cham, Switzerland: Springer International Publishing; 2017. pp. 227-40.