Cardioprotective Effect of Antiviral Therapy Among Hepatitis C Infected Patients: A Meta-Analysis
Author Type(s)
Resident/Fellow
Document Type
Article
Publication Date
12-1-2023
DOI
10.1016/j.ijcha.2023.101270
Journal Title
International Journal of Cardiology. Heart & Vasculature
Department
Medicine
Abstract
BACKGROUND: Hepatitis C (HCV) infections have been shown to be associated a with higher risk of atherosclerotic cardiovascular disease (CVD). However, the use of antiviral therapy (AVT) and the risk of CVD has not been well established with limited literature.
OBJECTIVE: We sought to evaluate the association between AVT use post-HCV infection and cardiovascular outcomes.
METHODS: We performed a systematic literature search using PubMed, Embase, and Scopus for relevant articles from inception until 10th March 2023. Primary clinical outcomes were the incidence of any CVD. Secondary endpoints were all-cause of mortality, stroke, myocardial infarction, and peripheral artery disease.
RESULTS: A total of 394,452 patients were included in the analysis (111,076 in the AVT group and 283,376 patients in the NAVT group). The mean age of patients among AVT and NAVT groups was comparable (58.7 vs 58.18). The pooled analysis of primary outcomes showed that AVT was associated with a significantly reduced risk of any CVD (HR, 0.55(95%CI: 0.41-0.75), P < 0.001) compared with the NAVT group of patients. Secondary outcomes including ACM (HR, 0.38(95%CI: 0.32-0.46), P < 0.001), MI (HR, 0.62(95%CI: 0.41-0.94), P = 0.02), and PAD (HR, 0.62(95%CI: 0.41-0.93), P = 0.02) were significantly lower among AVT groups compared with NAVT groups of patients with HCV infection. However, the risk of stroke was comparable between both groups of patients (HR, 0.79(95%CI: 0.58-1.07), P = 0.13).
CONCLUSION: Our analysis shows HCV-infected patients post-AVT have a significantly lower risk of any CVD, MI, ACM, and PAD compared with NAVT groups of patients.
Recommended Citation
Jaiswal, V., Ang, S., Hanif, M., Jha, M., Kumar, V., Siddiq, A., Vachhani, B., Halder, A., Koifman, M., Jeanty, H., Soni, S., Subhan Waleed, M., Kumar, T., Huang, H., & Bandyopadhyay, D. (2023). Cardioprotective Effect of Antiviral Therapy Among Hepatitis C Infected Patients: A Meta-Analysis. International Journal of Cardiology. Heart & Vasculature, 49, 101270-101270. https://doi.org/10.1016/j.ijcha.2023.101270