Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection
Author Type(s)
Student
Document Type
Article
Publication Date
5-15-2021
DOI
10.1158/1078-0432.CCR-20-4382
Journal Title
Clinical Cancer Research
Abstract
PURPOSE: Perineural invasion (PNI) is associated with aggressive tumor behavior, recurrence, and metastasis, and can influence the administration of adjuvant treatment. However, standard histopathologic examination has limited sensitivity in detecting PNI and does not provide insights into its mechanistic underpinnings.
EXPERIMENTAL DESIGN: A multivariate Cox regression was performed to validate associations between PNI and survival in 2,029 patients across 12 cancer types. Differential expression and gene set enrichment analysis were used to learn PNI-associated programs. Machine learning models were applied to build a PNI gene expression classifier. A blinded re-review of hematoxylin and eosin (H&E) slides by a board-certified pathologist helped determine whether the classifier could improve occult histopathologic detection of PNI.
RESULTS: PNI associated with both poor overall survival [HR, 1.73; 95% confidence interval (CI), 1.27-2.36;
CONCLUSIONS: This study provides salient biological insights regarding PNI and demonstrates a role for gene expression classifiers to augment detection of histopathologic features.
Recommended Citation
Guo, J. A., Zhao, D., & Hwang, W. L. (2021). Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection. Clinical Cancer Research, 27 (10), 2807-2815. https://doi.org/10.1158/1078-0432.CCR-20-4382
Comments
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