Management of Isocitrate Dehydrogenase 1/2 Mutated Acute Myeloid Leukemia
Author Type(s)
Student
Document Type
Article
Publication Date
5-1-2024
DOI
10.1038/s41375-024-02246-2
Journal Title
Leukemia
Abstract
The emergence of next generation sequencing and widespread use of mutational profiling in acute myeloid leukemia (AML) has broadened our understanding of the heterogeneous molecular basis of the disease. Since genetic sequencing has become a standard practice, several driver mutations have been identified. Accordingly, novel targeted therapeutic agents have been developed and are now approved for the treatment of subsets of patients that carry mutations in FLT3, IDH1, and IDH2 [1, 2]. The emergence of these novel agents in AML offers patients a new modality of therapy, and shifts treatment paradigms toward individualized medicine. In this review, we outline the role of IDH mutations in malignant transformation, focus in on a novel group of targeted therapeutic agents directed toward IDH1- and IDH2-mutant AML, and explore their impact on prognosis in patients with AML.
Recommended Citation
Fruchtman, H., Avigan, Z., Waksal, J., Brennan, N., & Mascarenhas, J. (2024). Management of Isocitrate Dehydrogenase 1/2 Mutated Acute Myeloid Leukemia. Leukemia, 38 (5), 927-935. https://doi.org/10.1038/s41375-024-02246-2
