TGF-β Signaling: Critical Nexus of Fibrogenesis and Cancer
Author Type(s)
Student
Document Type
Article
Publication Date
6-26-2024
DOI
10.1186/s12967-024-05411-4
Journal Title
Journal of Translational Medicine
Abstract
The transforming growth factor-beta (TGF-β) signaling pathway is a vital regulator of cell proliferation, differentiation, apoptosis, and extracellular matrix production. It functions through canonical SMAD-mediated processes and noncanonical pathways involving MAPK cascades, PI3K/AKT, Rho-like GTPases, and NF-κB signaling. This intricate signaling system is finely tuned by interactions between canonical and noncanonical pathways and plays key roles in both physiologic and pathologic conditions including tissue homeostasis, fibrosis, and cancer progression. TGF-β signaling is known to have paradoxical actions. Under normal physiologic conditions, TGF-β signaling promotes cell quiescence and apoptosis, acting as a tumor suppressor. In contrast, in pathological states such as inflammation and cancer, it triggers processes that facilitate cancer progression and tissue remodeling, thus promoting tumor development and fibrosis. Here, we detail the role that TGF-β plays in cancer and fibrosis and highlight the potential for future theranostics targeting this pathway.
Recommended Citation
Giarratana, A., Prendergast, C., Salvatore, M., & Capaccione, K. (2024). TGF-β Signaling: Critical Nexus of Fibrogenesis and Cancer. Journal of Translational Medicine, 22 (1), 594-594. https://doi.org/10.1186/s12967-024-05411-4
