Copper Homeostasis and Copper-Induced Cell Death in Tumor Immunity: Implications for Therapeutic Strategies in Cancer Immunotherapy
Author Type(s)
Student
Document Type
Article
Publication Date
12-1-2024
DOI
10.1186/s40364-024-00677-8
Journal Title
Biomarker Research
Keywords
Cancer immunotherapy, Copper homeostasis, Copper metabolism, Cuproptosis
Disciplines
Medicine and Health Sciences
Abstract
Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense. Maintaining copper homeostasis is critical for human health, and its imbalance has been linked to various diseases, especially cancer. Cuproptosis, a novel mechanism of copper-induced cell death, provides new therapeutic opportunities for metal ion regulation to interact with cell fate. This review provides insights into the complex mechanisms of copper metabolism, the molecular basis of cuproptosis, and its association with cancer development. We assess the role of cuproptosis-related genes (CRGs) associated with tumorigenesis, their importance as prognostic indicators and therapeutic targets, and the impact of copper homeostasis on the tumor microenvironment (TME) and immune response. Ultimately, this review highlights the complex interplay between copper, cuproptosis, and cancer immunotherapy.
Recommended Citation
Zhang, S., Huang, Q., Ji, T., Li, Q., & Hu, C. (2024). Copper Homeostasis and Copper-Induced Cell Death in Tumor Immunity: Implications for Therapeutic Strategies in Cancer Immunotherapy. Biomarker Research, 12 (1). https://doi.org/10.1186/s40364-024-00677-8
