Event Title
Research Day Distinguished Keynote Speaker: How to Teach Old Drugs New Tricks
Type
Speech
Location
New York, NY
Start Date
1-5-2018 1:15 PM
End Date
1-5-2018 2:00 PM
Description
Dr. Shoelson discussed relevant concepts relating potential roles of obesity in the pathophysiology of type 2 diabetes (T2D) and cardiovascular disease (CVD) prior to describing the clinical trials his team conducted to determine that the world's oldest anti-inflammatory drug, salicylate, lowers blood glucose in patients with T2D. He then delves into mechanism to show how this occurs. He then showed why uric acid is elevated in obesity, and how this affects normal physiology by depleting upstream purine metabolites in liver and adipose tissue. He also showed that xanthine oxidase inhibitors including allopurinol restore the depleted purines to affect the same major metabolic pathways targeted by salicylate.
Research Day Distinguished Keynote Speaker: How to Teach Old Drugs New Tricks
New York, NY
Dr. Shoelson discussed relevant concepts relating potential roles of obesity in the pathophysiology of type 2 diabetes (T2D) and cardiovascular disease (CVD) prior to describing the clinical trials his team conducted to determine that the world's oldest anti-inflammatory drug, salicylate, lowers blood glucose in patients with T2D. He then delves into mechanism to show how this occurs. He then showed why uric acid is elevated in obesity, and how this affects normal physiology by depleting upstream purine metabolites in liver and adipose tissue. He also showed that xanthine oxidase inhibitors including allopurinol restore the depleted purines to affect the same major metabolic pathways targeted by salicylate.
