The Association Between Anemia of Chronic Inflammation and Alzheimer's Disease and Related Dementias

Authors

• Alexander Andreev
• Burak Erdinc
• Kiran Shivaraj
• Julia Schmutz
• Olga Levochkina
• Dhrity Bhowmik
• Fady Farag
• Kelli M Money
• Louis H. Primavera, Touro CollegeFollow
• Vladimir Gotlieb
• Sonu Sahni, Touro CollegeFollow

Document Type

Article

Publication Date

9-18-2020

Publication Title

J Alzheimers Dis Rep

DOI

10.3233/ADR-200178

Abstract

Background: Dementia is a spectrum of neurological diseases characterized by memory impairment and cognitive decline with the pathogenesis and effective management remaining elusive. Several studies have identified a correlation between anemia and Alzheimer's disease and related dementias (ADRD); however, anemia subtypes and association with ADRD have yet to be studied conclusively.

Objective: To study an association between ADRD and anemia of chronic inflammation.

Methods: We conducted a retrospective case-control study of the patients, diagnosed with ADRD at Brookdale Hospital. Pair-wise comparisons between means of controls and cases in terms of iron studies and laboratory results were performed using a Mann-Whitney U test. Pair-wise comparisons between anemia subgroups (moderate and severe) were performed using a Two Sample proportion Z-Test, where for each couple of normally distributed population.

Results: There was a total of 4,517 (1,274 ADRD group; 3,243 Control group) patients. There was significant difference in hemoglobin 10.15 versus 11.04 [

Conclusion: We demonstrated an association between ADRD and anemia of chronic inflammation independent of age, renal function, and HgbA1C levels.

Comments

Originally published in Journal of Alzheimer's Disease Reports. See https://doi.org/10.3233/ADR-200178

Recommended Citation

Andreev, A., Erdinc, B., Shivaraj, K., Schmutz, J., Levochkina, O., Bhowmik, D., Farag, F., Money, K., Primavera, L. H., Gotlieb, V., & Sahni, S. (2020). The Association Between Anemia of Chronic Inflammation and Alzheimer's Disease and Related Dementias. J Alzheimers Dis Rep, 4 (1), 379-391. https://doi.org/10.3233/ADR-200178

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License