Document Type
Article
Publication Date
2017
Abstract
We recently reported a case in which a 54-year-old male experienced maintenance insomnia, generalized anxiety and panic symptoms associated with consumption of a fish oil supplement enriched in eicosapentaenoic acid (EPA). We report here that the same patient has experienced identical but more severe symptoms in response to the use of the leukotriene receptor antagonist montelukast, in accordance with other cases reported to the Food and Drug Administration. Since omega-3 fatty acids like EPA are precursors for the biosynthesis of eicosanoids including leukotrienes, a common factor to these psychiatric adverse events may be perturbations in this highly complex system of lipid inflammatory mediators.
Recommended Citation
McCarter, G., & Blanchard, L. B. (2017). Similar Adverse Events from Two Disparate Agents Implicate Lipid Inflammatory Mediators for a Role in Anxiety States. Oxford Medical Case Reports, 2017 (11), [Article omx060]. https://doi.org/10.1093/omcr/omx060
Publisher's Statement
Originally published in Oxford Medical Case Reports, 2017(11) [Article omx060]. Licensed under CC BY-NC 4.0. The original material can be found here.
