Document Type

Article

Publication Date

2017

Publication Title

Oxford Medical Case Reports

DOI

10.1093/omcr/omx060

Abstract

We recently reported a case in which a 54-year-old male experienced maintenance insomnia, generalized anxiety and panic symptoms associated with consumption of a fish oil supplement enriched in eicosapentaenoic acid (EPA). We report here that the same patient has experienced identical but more severe symptoms in response to the use of the leukotriene receptor antagonist montelukast, in accordance with other cases reported to the Food and Drug Administration. Since omega-3 fatty acids like EPA are precursors for the biosynthesis of eicosanoids including leukotrienes, a common factor to these psychiatric adverse events may be perturbations in this highly complex system of lipid inflammatory mediators.

Publisher's Statement

Originally published in Oxford Medical Case Reports, 2017(11) [Article omx060]. Licensed under CC BY-NC 4.0. The original material can be found here.

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