NYMC Faculty Publications

T Cell Fibronectin and Mycobacterial Adversarial Strategy

Journal Title

International Journal of Clinical & Laboratory Research

First Page

121

Last Page

123

Document Type

Article

Publication Date

January 1993

Department

Pathology, Microbiology and Immunology

Abstract

Sensitized T cells synthesize and secrete a biochemically and functionally distinct cellular fibronectin in response to antigenic stimulation. This T cell fibronectin is associated with initiation of in vivo delayed hypersensitivity inflammatory reactions. Mycobacterial secretory proteins of the fibronectin-binding antigen 85 complex can bind and inactivate T cell fibronectin, and diminish expression of anti-mycobacterial delayed hypersensitivity. Interaction of T cell fibronectin and antigen 85 provides an additional possible mechanism for tuberculin anergy in patients with clinical tuberculosis.

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