NYMC Faculty Publications

Cloning and Characterization of Human TNF Alpha Promoter Region

Author Type(s)

Faculty

Additional Author Affiliation

Touro College of Dental Medicine at NYMC

DOI

10.1016/0378-1119(93)90314-S

Journal Title

Gene

First Page

307

Last Page

308

Document Type

Article

Publication Date

9-15-1993

Department

Pharmacology

Abstract

We report the sequence of a 1.2-kb human tumor necrosis factor alpha (TNF alpha) promoter region, which was cloned using PCR. The sequence has several variations from two previous reports and exhibits many potential DNA-binding sites specific to mammalian gene regulatory proteins inducible by lipopolysaccharides.

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