NYMC Faculty Publications
A Novel Non-ataxic Guinea Pig Strain With Cerebrocortical and Cerebellar Abnormalities
DOI
10.1016/0006-8993(93)91002-A
Journal Title
Brain Research
First Page
325
Last Page
331
Document Type
Article
Publication Date
March 1993
Department
Pathology, Microbiology and Immunology
Abstract
This is the first description of GS guinea pigs, a partially inbred, non-ataxic, albino Peruvian (long-hair) strain with abnormal motor behavior and seizures. GS guinea pigs show gross and microscopic cerebellar and microscopic cerebrocortical abnormalities compared to Hartley strain animals. There is little difference between GS and short-hair guinea pig strains in Purkinje cell function, electrically evoked Ca2+ transients or immune responsiveness. The GS strain may prove useful in studying altered functions of the cerebellum in human disease.
Recommended Citation
Lev-Ram, V., Valsamis, M., Masliah, E., Levine, S., Godfrey, H., & Godfrey, H. (1993). A Novel Non-ataxic Guinea Pig Strain With Cerebrocortical and Cerebellar Abnormalities. Brain Research, 606 (2), 325-331. https://doi.org/10.1016/0006-8993(93)91002-A
