NYMC Faculty Publications

Seasonal Variation of Induction of Contact Sensitivity and of Lymph Node T Lymphocytes in Guinea Pigs

Journal Title

International Archives of Allergy and Applied Immunology

First Page

411

Last Page

414

Document Type

Article

Publication Date

January 1975

Department

Pathology, Microbiology and Immunology

Abstract

Guinea pigs sensitized with dinotrophenyl thiocyanate in complete Freund's adjuvant from November to February developed markedly lower contact sensitivity than animals sensitized during the rest of the year. The percentage of T cell rosettes (lymphocytes forming spontaneous rosettes with normal rabbit red cells) was concomitantly reduced in the lymph nodes but not in thymus or bone marrow during the winter months.

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