NYMC Faculty Publications

Does Resource Availability Help Determine the Evolutionary Route to Multicellularity?

DOI

10.1111/ede.12287

Journal Title

Evolution & Development

First Page

115

Last Page

119

Document Type

Letter to the Editor

Publication Date

May 2019

Department

Cell Biology and Anatomy

Abstract

Genetic heterogeneity and homogeneity are associated with distinct sets of adaptive advantages and bottlenecks, both in developmental biology and population genetics. Whereas populations of individuals are usually genetically heterogeneous, most multicellular metazoans are genetically homogeneous. Observing that resource scarcity fuels genetic heterogeneity in populations, we propose that monoclonal development is compatible with the resource-rich and stable internal environments that complex multicellular bodies offer. In turn, polyclonal development persists in tumors and in certain metazoans, both exhibiting a closer dependence on external resources. This eco-evo-devo approach also suggests that multicellularity may originally have emerged through polyclonal development in early metazoans, because of their reduced shielding from environmental fluctuations.

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