NYMC Faculty Publications
Cardiotoxicity of Cancer Chemotherapy in Clinical Practice
DOI
10.1080/21548331.2018.1530831
Journal Title
Hospital Practice
First Page
6
Last Page
15
Document Type
Article
Publication Date
February 2019
Department
Medicine
Abstract
Several anticancer agents are associated with significant cardiotoxicity. The list of cardiotoxic cancer therapeutic agents includes anthracyclines, trastuzumab, alkylating agents, antimetabolites, which have been in use for decades; and recently introduced anticancer therapies such as tyrosine kinase inhibitors, angiogenesis inhibitors, checkpoint inhibitors and proteasome inhibitors. Cardiac imaging using echocardiography, nuclear imaging techniques, and magnetic resonance (MR) imaging can help in the early detection of chemotherapy-related cardiotoxicity. This can prevent the morbidity and mortality resulting from the cardiotoxicity of these agents. Further research is needed to improve our understanding of the underlying mechanism of their cardiotoxicity and to develop newer preventive and therapeutic strategies for chemotherapy related cardiotoxicity.
Recommended Citation
Jain, D., & Aronow, W. (2019). Cardiotoxicity of Cancer Chemotherapy in Clinical Practice. Hospital Practice, 47 (1), 6-15. https://doi.org/10.1080/21548331.2018.1530831