NYMC Faculty Publications

Plasma Metabolomic Analysis Indicates Flavonoids and Sorbic Acid Are Associated With Incident Diabetes: A Nested Case-Control Study Among Women's Interagency HIV Study Participants

Authors

Elaine A. Yu, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America.
José O. Alemán, Laboratory of Translational Obesity Research, New York University Grossman School of Medicine, New York, New York, United States of America.
Donald R. Hoover, Department of Statistics and Biostatistics, Institute for Health, Health Care Policy and Aging Research, Rutgers University, New Brunswick, New Jersey, United States of America.
Qiuhu Shi, New York Medical College, Valhalla, New York, United States of America.
Michael Verano, Laboratory of Translational Obesity Research, New York University Grossman School of Medicine, New York, New York, United States of America.
Kathryn Anastos, Montefiore Medical Center, Bronx, New York, United States of America.Follow
Phyllis C. Tien, University of California, San Francisco, California, United States of America.
Anjali Sharma, Montefiore Medical Center, Bronx, New York, United States of America.
Ani Kardashian, University of Southern California, Los Angeles, California, United States of America.
Mardge H. Cohen, Cook County Health & Hospitals System and Rush University, Chicago, Illinois, United States of America.
Elizabeth T. Golub, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Katherine G. Michel, Georgetown University School of Medicine, District of Columbia, United States of America.
Deborah R. Gustafson, State University of New York Downstate Health Sciences University, New York, New York, United States of America.
Marshall J. Glesby, Division of Infectious Diseases, Weill Cornell Medicine, New York, New York, United States of America.

Author Type(s)

Faculty

DOI

10.1371/journal.pone.0271207

Journal Title

PLOS One

First Page

e0271207

Document Type

Article

Publication Date

1-1-2022

Department

Public Health

Abstract

INTRODUCTION: Lifestyle improvements are key modifiable risk factors for Type 2 diabetes mellitus (DM) however specific influences of biologically active dietary metabolites remain unclear. Our objective was to compare non-targeted plasma metabolomic profiles of women with versus without confirmed incident DM. We focused on three lipid classes (fatty acyls, prenol lipids, polyketides). MATERIALS AND METHODS: Fifty DM cases and 100 individually matched control participants (80% with human immunodeficiency virus [HIV]) were enrolled in a case-control study nested within the Women's Interagency HIV Study. Stored blood samples (1-2 years prior to DM diagnosis among cases; at the corresponding timepoint among matched controls) were assayed in triplicate for metabolomics. Time-of-flight liquid chromatography mass spectrometry with dual electrospray ionization modes was utilized. We considered 743 metabolomic features in a two-stage feature selection approach with conditional logistic regression models that accounted for matching strata. RESULTS: Seven features differed by DM case status (all false discovery rate-adjusted q<0.05). Three flavonoids (two flavanones, one isoflavone) were respectively associated with lower odds of DM (all q<0.05), and sorbic acid was associated with greater odds of DM (all q<0.05). CONCLUSION: Flavonoids were associated with lower odds of incident DM while sorbic acid was associated with greater odds of incident DM.

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