POLDIP3: At the Crossroad of RNA and DNA Metabolism

Authors

Manrose Singh, Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Blvd, Old Westbury, NY 11568, USA.
Sufang Zhang, Department Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.
Alexis M. Perez, Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Blvd, Old Westbury, NY 11568, USA.
Ernest Y. Lee, Department Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.
Marietta Y. Lee, Department Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA.
Dong Zhang, Department of Biomedical Sciences, College of Osteopathic Medicine, New York Institute of Technology, Northern Blvd, Old Westbury, NY 11568, USA.

Author Type(s)

Faculty

Journal Title

Genes

Document Type

Article

Publication Date

10-22-2022

Department

Biochemistry and Molecular Biology

Abstract

POLDIP3 was initially identified as a DNA polymerase delta (Pol δ) interacting protein almost twenty years ago. Intriguingly, it also interacts with proteins involved in a variety of RNA related biological processes, such as transcription, pre-mRNA splicing, mRNA export, and translation. Studies in recent years revealed that POLDIP3 also plays critical roles in disassembling genome wide R-loop formation and activating the DNA damage checkpoint in vivo. Here, we review the functions of POLDIP3 in various RNA and DNA related cellular processes. We then propose a unified model to illustrate how POLDIP3 plays such a versatile role at the crossroad of the RNA and DNA metabolism.

Recommended Citation

Singh, M., Zhang, S., Perez, A. M., Lee, E. Y., Lee, M. Y., & Zhang, D. (2022). POLDIP3: At the Crossroad of RNA and DNA Metabolism. Genes, 13 (11). https://doi.org/10.3390/genes13111921