CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non-Small Cell Lung Cancer

Authors

Xuehan Chen, Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Yanzhuo Liu, Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Yang Wang, Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Chenlong Wang, Department of Pharmacy, Zhongnan Hospital of Wuhan University, Wuhan, China.
Xuewei Chen, Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
Yu Xiong, Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Lilong Liu, Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Xi Yuan, Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Honglin Tang, Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Chong Shu, Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Jing Zhang, Animal Experimental Center of Wuhan University, Wuhan, China.
Austin M. Guo, Department of Pharmacology, New York Medical College, Valhalla, New York.
Honglei Chen, Department of Pathology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Jing Yang, Department of Pharmacology and Hubei Province Key Laboratory of Allergy and Immune-related Diseases, School of Basic Medical Sciences, Wuhan University, Wuhan, China.

Author Type(s)

Faculty

DOI

10.1158/0008-5472.CAN-21-4029

Journal Title

Cancer Research

First Page

4016

Last Page

4030

Document Type

Article

Publication Date

11-2-2022

Department

Pharmacology

Abstract

The identification of a role for CYP4F2-dependent metabolism in driving immune evasion in non-small cell lung cancer reveals a strategy to improve the efficacy of immunotherapy by inhibiting CYP4F2. See related article by Van Ginderachter, p. 3882.

Recommended Citation

Chen, X., Liu, Y., Wang, Y., Wang, C., Chen, X., Xiong, Y., Liu, L., Yuan, X., Tang, H., Shu, C., Zhang, J., Guo, A. M., Chen, H., & Yang, J. (2022). CYP4F2-Catalyzed Metabolism of Arachidonic Acid Promotes Stromal Cell-Mediated Immunosuppression in Non-Small Cell Lung Cancer. Cancer Research, 82 (21), 4016-4030. https://doi.org/10.1158/0008-5472.CAN-21-4029