NYMC Faculty Publications

Critical Care Cardiology Trials Network (CCCTN): A Cohort Profile

Thomas S. Metkus, Divisions of Cardiology and Cardiac Surgery, Departments of Medicine and Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Vivian M. Baird-Zars, Levine Cardiac Intensive Care Unit, TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Carlos E. Alfonso, Division of Cardiology, Department of Medicine; University of Miami Hospital & Clinics, University of Miami Miller School of Medicine, Miami, FL 33136, USA.
Carlos L. Alviar, Leon H. Charney Division of Cardiology, NYU Langone Medical Center, New York 10016 NY, USA.
Christopher F. Barnett, Division of Cardiology, Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA.
Gregory W. Barsness, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902, USA.
David D. Berg, Levine Cardiac Intensive Care Unit, TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Mia Bertic, University of Toronto Etobicoke,Toronto ON, Canada.
Erin A. Bohula, Levine Cardiac Intensive Care Unit, TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
James Burke, Lehigh Valley Heart Institute, Allentown, PA 18103, USA.
Barry Burstein, University of Toronto, Toronto, ON, Canada.
Sunit-Preet Chaudhry, StVincent Heart Center, Indianapolis, IN 46260, USA.
Howard A. Cooper, Westchester Medical Center and New York Medical College, Valhalla NY 10901, USA.
Lori B. Daniels, Division of Cardiovascular Medicine La Jolla, UCSD, San Diego, CA 92037, USA.
Christopher B. Fordyce, UBC Centre for Cardiovascular Innovation, Cardiovascular Health Program, UBC Centre for Health Evaluation & Outcomes Sciences, University of British Columbia, Vancouver, BC, Canada.
Shahab Ghafghazi, Division of Cardiovascular Medicine, University of Louisville, Louisville, KY 40202, USA.
Michael Goldfarb, Division of Cardiology, Jewish General Hospital, McGill University, Montréal, QC, Canada.
Jason N. Katz, Division of Cardiology, Duke University School of Medicine, Durham, NC 27710, USA.
Ellen C. Keeley, Division of Cardiology, Department of Medicine, University of Florida, Gainesville, FL 32610, USA.
Norma M. Keller, Department of Medicine at NYU Grossman School of Medicine, Bellevue Hospital, New York NY 10016, USA.
Benjamin Kenigsberg, Departments of Cardiology and Critical Care Medicine, MedStar Washington Hospital Center, Washington DC, WA 20010, USA.
Michael C. Kontos, Division of Cardiology, Virginia Commonwealth University, Richmond, VA 23219, USA.
Younghoon Kwon, Division of Cardiology, University of Washington, Seattle, WA 98104, USA.
Patrick R. Lawler, Peter Munk Cardiac Centre, Toronto General Hospital, University of Toronto, Toronto ON, Canada.
Evan Leibner, Department of Emergency Medicine, Icahn School of Medicine at Mount Sinai, The Mount Sinai Hospital, New York, NY 10029, USA.
Shuangbo Liu, Max Rady College of Medicine St. Boniface Hospital Winnipeg, Manitoba, Canada.
Venu Menon, Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
P Elliott Miller, Department of Cardiovascular Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
L Kristin Newby, Divison of Cardiology, Duke University School of Medicine, Durham, NC 27710, USA.
Connor G. O'Brien, Department of Medicine, Division of Cardiology, University of California-San Francisco School of Medicine, San Francisco, CA 94143, USA.
Alexander I. Papolos, Departments of Cardiology and Critical Care Medicine, MedStar Washington Hospital Center, Washington DC, WA 20010, USA.
Matthew J. Pierce

Author Type(s)

Faculty

Journal Title

European Heart Journal. Quality of Care & Clinical Outcomes

First Page

703

Last Page

708

Document Type

Article

Publication Date

10-26-2022

Department

Medicine

Abstract

AIMS: The aims of the Critical Care Cardiology Trials Network (CCCTN) are to develop a registry to investigate the epidemiology of cardiac critical illness and to establish a multicentre research network to conduct randomised clinical trials (RCTs) in patients with cardiac critical illness. METHODS AND RESULTS: The CCCTN was founded in 2017 with 16 centres and has grown to a research network of over 40 academic and clinical centres in the United States and Canada. Each centre enters data for consecutive cardiac intensive care unit (CICU) admissions for at least 2 months of each calendar year. More than 20 000 unique CICU admissions are now included in the CCCTN Registry. To date, scientific observations from the CCCTN Registry include description of variations in care, the epidemiology and outcomes of all CICU patients, as well as subsets of patients with specific disease states, such as shock, heart failure, renal dysfunction, and respiratory failure. The CCCTN has also characterised utilization patterns, including use of mechanical circulatory support in response to changes in the heart transplantation allocation system, and the use and impact of multidisciplinary shock teams. Over years of multicentre collaboration, the CCCTN has established a robust research network to facilitate multicentre registry-based randomised trials in patients with cardiac critical illness. CONCLUSION: The CCCTN is a large, prospective registry dedicated to describing processes-of-care and expanding clinical knowledge in cardiac critical illness. The CCCTN will serve as an investigational platform from which to conduct randomised controlled trials in this important patient population.

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