Diagnosis and Management of Mature B-Cell Lymphomas in Children, Adolescents, and Young Adults

Authors

Stanton Goldman, Department of Pediatric Hematology/Oncology/Stem Cell Transplantation, Medical City Children's Hospital, Dallas, TX, USA. Electronic address: stan.goldman@usoncology.com.
Mitchell S. Cairo, Department of Pediatrics, New York Medical College, Valhalla, NY, USA; Department of Pathology, New York Medical College, Valhalla, NY, USA; Department of Epidemiology and Community Health, New York Medical College, Valhalla, NY, USA; Department of Medicine, New York Medical College, Valhalla, NY, USA; Department of Microbiology and Immunology, New York Medical College, Valhalla, NY, USA; Department of Cell Biology and Anatomy, New York Medical College, Valhalla, NY, USA.Follow

Author Type(s)

Faculty

DOI

10.1016/j.beha.2023.101463

Journal Title

Best Practice & Research. Clinical Haematology

First Page

101463

Document Type

Article

Publication Date

6-1-2023

Department

Pediatrics

Abstract

Mature B-cell lymphoma in children, adolescents and young adults comprises three major histological subtypes including in order of frequency Burkitt, germinal center diffuse large B-cell lymphoma and primary mediastinal B-cell lymphoma. The cure rate of the first two with aggressive short chemotherapy based on clinical grouping is ∼90% in resource rich countries. Recent data has shown that incorporation of immune therapy has enhanced event free survival in advanced patients. Future studies will address the possibility of reducing the burden of chemotherapy by substitution of immune based therapies.

Recommended Citation

Goldman, S., & Cairo, M. S. (2023). Diagnosis and Management of Mature B-Cell Lymphomas in Children, Adolescents, and Young Adults. Best Practice & Research. Clinical Haematology, 36 (2), 101463. https://doi.org/10.1016/j.beha.2023.101463