Diagnosis and Management of Hodgkin Lymphoma in Children, Adolescents, and Young Adults

Authors

Jennifer A. Belsky, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: jbelsky@iu.edu.
Jessica Hochberg, Pediatrics, New York Medical College, Valhalla, NY, USA.
Lisa Giulino-Roth, Division of Pediatric Hematology/Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA.

Author Type(s)

Faculty

Journal Title

Best Practice & Research. Clinical Haematology

First Page

101445

Document Type

Article

Publication Date

3-1-2023

Department

Pediatrics

Abstract

Advances in the management of Hodgkin lymphoma in children, adolescents and young adult have resulted in survival outcomes exceeding 90%. The risk of late toxicity, however, remains a significant concern for survivors of HL and the focus of modern trials have been to advance cure rates while reducing long term toxicity. This has been accomplished through response-adapted treatment approaches and the incorporation of novel agents, many of which target the unique interaction between the Hodgkin and Reed Sternberg cells and the tumor microenvironment. In addition, an improved understanding of prognostic markers, risk stratification, and the biology of this entity in children and AYAs may allow us to further tailor therapy. This review focuses on the current management of HL in the upfront and relapsed settings, recent advances in novel agents that target HL and the tumor microenvironment, and promising prognostic markers that may help guide the future management of HL.

Recommended Citation

Belsky, J. A., Hochberg, J., & Giulino-Roth, L. (2023). Diagnosis and Management of Hodgkin Lymphoma in Children, Adolescents, and Young Adults. Best Practice & Research. Clinical Haematology, 36 (1), 101445. https://doi.org/10.1016/j.beha.2023.101445