NYMC Faculty Publications

Exosomes, Microvesicles, and Other Extracellular Vesicles-A Keystone Symposia Report

Jennifer Cable, PhD Science Writer, New York, New York, USA.
Kenneth W. Witwer, Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Robert J. Coffey, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Aleksandar Milosavljevic, Department of Molecular and Human Genetics; Dan L Duncan Comprehensive Cancer Center; and Program in Quantitative and Computational Biosciences, Baylor College of Medicine, Houston, Texas, USA.
Ariana K. von Lersner, Program in Cancer Biology, Vanderbilt University, Nashville, Tennessee, USA.
Lizandra Jimenez, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Ferdinando Pucci, Department of Otolaryngology-Head and Neck Surgery; Department of Cell, Developmental & Cancer Biology; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.
Maureen M. Barr, Department of Genetics and Human Genetics Institute of New Jersey, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.
Niek Dekker, Protein Sciences, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Bahnisikha Barman, Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Daniel Humphrys, University of Washington, Seattle, Washington, USA.
Justin Williams, University of California, Berkeley, Berkeley, California, USA.
Michele de Palma, Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL); Agora Cancer Research Center; and Swiss Cancer Center Léman (SCCL), Lausanne, Switzerland.
Wei Guo, Department of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nuno Bastos, i3S Instituto de Investigação e Inovação em Saúde; IPATIMUP Institute of Molecular Pathology and Immunology; and ICBAS Instituto de Ciencias Biomédicas Abel Salazar, University of Porto, Porto, Portugal.
Andrew F. Hill, Research Centre for Extracellular Vesicles; Department of Biochemistry and Chemistry, School of Agriculture, Biomedicine and Environment, La Trobe University and Institute for Health and Sport, Victoria University, Melbourne, Victoria, Australia.
Efrat Levy, Center for Dementia Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York, USA.
Michael P. Hantak, Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, Utah, USA.
Clair Crewe, Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Elena Aikawa, Center for Interdisciplinary Cardiovascular Sciences, Division of Cardiovascular Medicine and Center for Excellence in Vascular Biology, Department of Medicine; Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Alan M. Adamczyk, University of Buenos Aires, Buenos Aires, Argentina.
Tamires M. Zanotto, Section of Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.
Matias Ostrowski, Facultad de Medicina, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Universidad de Buenos Aires (UBA) and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Tanina Arab, Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Daniel C. Rabe, Mass General Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA.
Aadil Sheikh, Department of Biology, College of Arts and Sciences, Baylor University, Waco, Texas, USA.
Danilo Rodrigues da Silva, University of Florida, Gainesville, Florida, USA.
Jennifer C. Jones, Translational Nanobiology Section, Laboratory of Pathology and Vaccine Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Chioma Okeoma, Department of Pharmacology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York, USA.
Thomas Gaborski, School of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, USA.
Qin Zhang, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Olesia Gololobova, Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Author Type(s)

Faculty

DOI

10.1111/nyas.14974

Journal Title

Annals of the New York Academy of Sciences

First Page

24

Last Page

37

Document Type

Article

Publication Date

5-1-2023

Department

Pathology, Microbiology and Immunology

Abstract

Extracellular vesicles (EVs) are small, lipid-bilayer-bound particles released by cells that can contain important bioactive molecules, including lipids, RNAs, and proteins. Once released in the extracellular environment, EVs can act as messengers locally as well as to distant tissues to coordinate tissue homeostasis and systemic responses. There is a growing interest in not only understanding the physiology of EVs as signaling particles but also leveraging them as minimally invasive diagnostic and prognostic biomarkers (e.g., they can be found in biofluids) and drug-delivery vehicles. On October 30-November 2, 2022, researchers in the EV field convened for the Keystone symposium "Exosomes, Microvesicles, and Other Extracellular Vesicles" to discuss developing standardized language and methodology, new data on the basic biology of EVs and potential clinical utility, as well as novel technologies to isolate and characterize EVs.

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