Acute Myeloid Leukemia and Fatal Scedosporium prolificans Sepsis After Eculizumab Treatment for Paroxysmal Nocturnal Hemoglobinuria: a Case Report

Authors

M Hanmantgad
Rajat Nog, New York Medical CollegeFollow
Karen Seiter, New York Medical CollegeFollow

DOI

10.21037/sci.2017.12.04

Journal Title

Stem Cell Investigation

First Page

100

Document Type

Article

Publication Date

12-22-2014

Department

Medicine

Abstract

Eculizumab has become the standard of care for patients with paroxysmal nocturnal hemoglobinuria (PNH). As more patients are treated, the long-term outcomes of these patients will become apparent. We recently treated a patient who developed PNH in the setting of aplastic anemia. The patient developed acute myeloid leukemia less than three years after initiating eculizumab. The patient also died suddenly from Scedosporium sepsis during induction therapy. This patient's course seemed more aggressive than would be expected. The possible effect of complement blockade is discussed.

Recommended Citation

Hanmantgad, M., Nog, R., & Seiter, K. (2014). Acute Myeloid Leukemia and Fatal Scedosporium prolificans Sepsis After Eculizumab Treatment for Paroxysmal Nocturnal Hemoglobinuria: a Case Report. Stem Cell Investigation, 4, 100. https://doi.org/10.21037/sci.2017.12.04

Publisher's Statement

Originally published in Stem Cell Investigation, 4, 100. The original material can be found here.