NYMC Faculty Publications

Acute Kidney Dysfunction in Patients With Chronic Hepatitis C Virus Infection: Analysis of Viral and Non-viral Factors

Author Type(s)

Faculty

DOI

10.1016/j.jceh.2014.01.004

Journal Title

Journal of Clinical and Experimental Hepatology

First Page

8

Last Page

13

Document Type

Article

Publication Date

3-1-2014

Department

Medicine

Disciplines

Medicine and Health Sciences

Abstract

BACKGROUND: Multiple studies have shown a relationship between chronic hepatitis C infection and chronic kidney disease. The prevalence, severity, underlying etiologies and predictors of acute kidney dysfunction (AKD) events in patients with hepatitis C has not been studied.

METHODS: We investigated viral and non-viral factors in the development renal dysfunction in 468 HCV patients retrospectively over a period of observation ranging from 3 months to 6 yrs.

RESULTS: A total of 124 AKD events occurred in 63 patients. On regression analysis; gender, race, alcohol abuse, HIV (Human immune deficiency virus) status, body mass index, baseline viral load (HCV-PCR), and genotype did not predict an event of AKD. Decompensated liver disease, history of IVDU, diabetes mellitus and baseline creatinine were independent predictors of AKD.

CONCLUSION: Development of AKD in patient with hepatitis C virus infection is independent of the genotype and viral load at baseline and is mostly predisposed by known prevalent factors in patients with hepatitis C such as diabetes, hypertension and intravenous drug use. Decompensated liver disease is the single most viral-related factor that predisposes for AKD.

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